Latest information about Gout

Gout May Be Linked to Raised Diabetes Risk: Study

Posted October 6, 2014

By Steven Reinberg
HealthDay Reporter

FRIDAY, Oct. 3, 2014 (HealthDay News) — Gout, a form of inflammatory arthritis, appears to increase the risk of type 2 diabetes, especially in women, a new study finds.

Researchers followed more than 35,000 gout sufferers in the United Kingdom and found that women with gout were 71 percent more likely to develop diabetes compared with people without gout. For men, the increased risk was 22 percent.

“Gout seems to be contributing to the risk of diabetes independently of other diabetes risk factors, such as obesity,” said lead researcher Dr. Hyon Choi, from the division of rheumatology, allergy, and immunology at Massachusetts General Hospital in Boston.

Gout causes intense pain and swelling in single joints, most often the feet, especially the joint at the base of the big toe. More than 3 million Americans suffer from the condition, men more often than women, according to the American College of Rheumatology.

People with gout have excess uric acid in the body, which forms needle-like crystals that lodge in the joints.

Diabetes, characterized by high blood sugar levels, can lead to kidney damage, heart disease and limb amputations over time. Clarifying its relationship to gout “is essential,” the study authors said.

However, while the current research suggests gout raises the risk of diabetes, the study can’t prove it. “The association is clearly there, but why that is so isn’t known,” Choi said.

Choi speculates that ongoing, low-level inflammation from gout may increase the risk for diabetes. Other risk factors shared by both diseases — high cholesterol and high blood pressure, for example — might also increase the risk, he said.

The researchers used data from health records on adult patients from January 1995 to May 2010. They zeroed in on about 35,000 people with newly diagnosed gout and compared them with more than 137,000 people without the condition.

To isolate the relationship between gout and diabetes, the investigators took age, sex and especially weight into account, because obesity is a risk factor for both gout and type 2 diabetes.

The study, published online Oct. 2 in the Annals of the Rheumatic Diseases, found that almost three-quarters of the new cases of gout were among men with an average age of 61. Among women with new cases of gout, the average age was 68.

The odds of developing diabetes alongside gout was much more likely for women, the researchers found. Choi said the absolute risk of a woman with gout developing diabetes is about 5 percent, and for a man it’s about 3 percent.

People with gout tended to drink more alcohol, saw their doctor more often, had more medical problems, and took steroids and diuretics more often than those who did not have gout, the study authors noted.

Treatments for gout are available and are tailored individually.

Choi said the best way to reduce the risk of developing gout or diabetes is to control risk factors, such as blood pressure, cholesterol and weight.

Dr. Spyros Mezitis, an endocrinologist at Lenox Hill Hospital in New York City, said this study may make doctors more aware of the association between gout and diabetes.

“The question for doctors is whether people with gout should be tested for diabetes and people with diabetes tested for gout,” Mezitis said.

“What this study tells us is that if the patient has gout, you have to be thinking that the patient is at increased risk for diabetes,” he said. This may be independent of other factors normally associated with diabetes, such as obesity and high blood pressure, he added.

Copyright © 2014 HealthDay. All rights reserved.

Alzheimer’s disease. What you need to know!

cinnamon Studies Show Cinnamon and B Vitamins can Help Prevent Alzheimers

By Dr. Mercola

In the United States, Alzheimer’s disease is currently at epidemic proportions, with 5.4 million Americans—including one in eight people aged 65 and over—living with the disease, according to the Alzheimer’s Association’s 2011 Alzheimer’s Disease Facts and Figures.

By 2050, this is expected to jump to 16 million, and in the next 20 years, it is projected that Alzheimer’s will affect one in four Americans, rivaling the current prevalence of obesity and diabetes.

There is still no known cure for this devastating disease, and very few treatments. Alzheimer’s drugs are often of little to no benefit at all, which underscores the importance of prevention throughout your lifetime.

Research repeatedly suggests the best hope for patients lies in prevention through optimal diet, exercise and staying socially and mentally active. As recently reported by Forbes:

“[A] new study in Science suggested that last year’s ‘breakthrough’ pharmaceutical, bexarotene (Targretin) – a cancer drug that had initially received wide publicity for helping break up the plaques in Alzheimer’s – doesn’t seem to do this very well at all, and can have significant adverse side effects for the patient.

‘Something happened in that initial report – either something technically or otherwise, which we can’t put our hands on at this point in time,” study author Sangram Sisodia told US News & World Report. ‘Something is seriously wrong.’

While memory loss is common among Westerners, it is NOT a “normal” part of aging. Research has shown that even mild “senior moments” are caused by the same brain lesions associated with Alzheimer’s disease and other forms of dementia. These cognitive changes are by no means inevitable!

People who experience very little decline in their cognitive function up until their deaths have been found (post-mortem) to be free of brain lesions, showing that it’sentirely possible to prevent the damage from occurring in the first place. At the end of this article, I share my best tips for maintaining healthy brain function well into old age.

In recent years, researchers studying natural compounds have offered new hope. For example, two recent studies suggest that compounds in cinnamon, as well as vitamins B12, B6, and folate may delay the onset and/or slow progression of the disease.

The Promise of Cinnamon and Vitamins in the Fight Against Alzheimer’s Disease

The first study in question, published in the Journal of Alzheimer’s Disease,found that cinnamaldehyde and epicatechin, two compounds found in cinnamon, have an inhibitory effect on the aggregation of a particular protein called tau. Tau plays a large role in the structure and function of neurons.

But while a normal part of cell structures, this protein can begin to accumulate, forming “neurofibrillary tangles” that are a hallmark of Alzheimer’s disease. Both compounds were found to protect tau from oxidative damage that can lead to dysfunction.

Donald Graves, adjunct professor in UCSB’s Department of Molecular, Cellular, and Developmental Biology and co-author of the study explained the protective process to Medical News Today:

“‘Take, for example, sunburn, a form of oxidative damage. If you wore a hat, you could protect your face and head from the oxidation. In a sense this cinnamaldehyde is like a cap. While it can protect the tau protein by binding to its vulnerable cysteine residues, it can also come off,’ Graves added, which can ensure the proper functioning of the protein.”

It’s interesting to note that there’s a high correlation between type 2 diabetes and Alzheimer’s disease. Some even believe Alzheimer’s may be a form of brain diabetes. Insulin and insulin receptors in your brain are crucial for learning and memory, and it’s known that these components are lower in people with Alzheimer’s disease.

In addition to the above findings, cinnamon has also been found to have beneficial effects on blood glucose management in type 2 diabetics. This is one of the reasons I include cinnamon in my healthy coconut candy recipe.

B Vitamins Again Show Promise in Alzheimer’s Prevention

The other study, published in Proceedings of the National Academy of Sciences, found that vitamins B6, B12, and folic acid may help slow the progression of the disease, confirming and supporting previous studies. As reported in the featured article:

“The fact that B-family vitamins may play a significant role in dementia, or more specifically in warding it off has been consistently illustrated. What is news from the current study, however, is that high-dose B-vitamin treatment in people at risk for the disease ‘slowed shrinkage of whole brain volume,’ and especially reduced shrinkage in areas known to be affected in Alzheimer’s disease.”

The 156 study participants, all of whom were over the age of 70, were diagnosed with mild cognitive impairment. This, along with midlife hypertension, midlife obesity and diabetes, is a known risk factor for Alzheimer’s. One group of participants received a placebo while the other received high-dose B-vitamin treatment consisting of:

  • 0.8 mg folic acid
  • 20 mg vitamin B6
  • 0.5 mg vitamin B12

It is important to note that vitamin B12 comes in many forms and it is typically injected because it is not absorbed well by most people, especially in the elderly who need it most. This is due to it being one of the largest vitamins known. The most common form is cyanocobalamin but a better from would be methylcobalamin. A better alternative to B12 injections would also be sublingual sprays, which are absorbed very similarly to the injections.

The treatment effectively slowed shrinkage of the whole brain volume over the course of two years. It also reduced, by as much as seven-fold, the cerebral atrophy in certain brain regions that are particularly vulnerable to damage associated with Alzheimer’s disease. Another major boon: The supplements cost less than 50 cents a day and are readily available in pharmacies and health-food stores. In the placebo group, higher homocysteine levels at baseline were associated with faster atrophy in these same regions. According to the researchers:

“We… show that the beneficial effect of B vitamins is confined to participants with high homocysteine… and that, in these participants, a causal Bayesian network analysis indicates the following chain of events: B vitamins lower homocysteine, which directly leads to a decrease in gray matter atrophy, thereby slowing cognitive decline.

Our results show that B-vitamin supplementation can slow the atrophy of specific brain regions that are a key component of the AD process and that are associated with cognitive decline.”

Dr. A. David Smith, professor emeritus of pharmacology at Oxford University, founding director of the Oxford Project to Investigate Memory and Ageing, and senior author of the study told Bloomberg News that this B-vitamin treatment is “the first and only disease-modifying treatment that’s worked. We have proved the concept that you can modify the disease.” This shouldn’t come as a surprise to anyone who understands that without proper nutrition and exercise, your brain will be increasingly vulnerable to damage with age…

Vitamin B Cocktail Already Used for Dementia Prevention in Sweden

Three years ago, the same group of researchers showed that the atrophy rate in patients’ whole brains was reduced by about 30 percent in those taking the vitamin cocktail. The atrophy rate was even higher—53 percent—in those who had elevated homocysteine levels, a benefit that was reconfirmed in the featured study. According to Bloomberg:

“The studies, known as Vitacog, were funded by seven charities and government agencies and vitamin maker Meda AB of Solna, Sweden. Smith is an inventor on three patents held by Oxford University for B vitamin formulations to treat Alzheimer’s disease… Vitamin B12 is found in liver, fish and milk and folic acid in fruit and vegetables. Deficiency of folate and B vitamins is already linked to dementia…

Doctors in Sweden began measuring homocysteine in people who report declining memory about two years ago, said [Johan] Lokk [professor and head physician in the geriatric department at Karolinska University Hospital in Sweden, who wasn’t involved in the study]...

Swedish patients with high homocysteine are given folic acid and B vitamins, even if they aren’t deficient. ‘We think the increased homocysteine level could be deleterious to the brain,’ Lokk said. ‘We wanted to be on the offensive in diagnosing and treating patients. In our opinion, it is harmless and cheap.’”

General Anesthesia Could Increase Risk of Dementia in Elderly by 35 Percent

Related research suggests that being exposed to general anesthesia can increase the risk of dementia in the elderly by as much as 35 percent. The research was presented at the annual congress of the European Society of Anesthesiology (ESA). As reported by Medical News Today:

“Postoperative cognitive dysfunction, or POCD, could be associated with dementia several years later. POCD is a common complication in elderly patients after major surgery. It has been proposed that there is an association between POCD and the development of dementia due to a common pathological mechanism through the amyloid β peptide. Several experimental studies suggest that some anesthetics could promote inflammation of neural tissues leading to POCD and/or Alzheimer’s disease (AD) precursors including β-amyloid plaques and neurofibrillary tangles.”

Participants aged 65 and over were followed for a total of 10 years. Participants exposed to at least one general anesthetic over the follow-up had a 35 percent increased risk of developing a dementia compared to those who were not exposed to anesthesia. According to lead researcher Dr. Francois Sztark:

“These results are in favor of an increased risk for dementia several years after general anesthesia. Recognition of POCD is essential in the perioperative management of elderly patients. A long-term follow-up of these patients should be planned.”

Tips for Avoiding Alzheimer’s Disease

The beauty of following my revised Nutrition Plan is that it helps treat and prevent all chronic degenerative diseases, from the common ones like heart disease, diabetes, obesity and Alzheimer’s to the ones you have never heard of or can’t even pronounce. So please read the Plan as soon as you can. It is divided into three helpful sections, Beginner, Intermediate and Advanced to help you start at the right level.

The plan is the first step in addressing Alzheimer’s disease, which is currently at epidemic proportions, with 5.4 million Americans – including one in eight people aged 65 and over – living with the disease.

Remember, while memory loss is indeed common among Westerners, it is NOT a “normal” part of aging, and cognitive changes are by no means inevitable. People who experience very little decline in their cognitive function up until their deaths have been found (post-mortem) to be free of brain lesions, showing that it’s entirely possible to prevent the damage from occurring in the first place… and one of the best ways to do this is by leading a healthy lifestyle.

  • Sugar and FructoseIdeally, you’ll want to keep your sugar levels to a minimum and your total fructose below 25 grams per day, or as low as 15 grams per day if you have insulin resistance or any related disorders.
  • Improve magnesium levels. There is some exciting preliminary research strongly suggesting a decrease in Alzheimer symptoms with increased levels of magnesium in the brain. Unfortunately, most magnesium supplements do not pass the blood brain levels, but a new one, magnesium threonate, appears to and holds some promise for the future for treating this condition and may be superior to other forms.
  • Optimize your vitamin D levels with safe sun exposure. Strong links between low levels of vitamin D in Alzheimer’s patients and poor outcomes on cognitive tests have been revealed. Researchers believe that optimal vitamin D levels may enhance the amount of important chemicals in your brain and protect brain cells by increasing the effectiveness of the glial cells in nursing damaged neurons back to health. Vitamin D may also exert some of its beneficial effects on Alzheimer’s through its anti-inflammatory and immune-boosting properties. Sufficient vitamin D is imperative for proper functioning of your immune system to combat inflammation that is also associated with Alzheimer’s.
  • Keep your fasting insulin levels below 3. This is indirectly related to fructose, as it will clearly lead to insulin resistance. However other sugars (sucrose is 50 percent fructose by weight), grains and lack of exercise are also important factors. Lowering insulin will also help lower leptin levels which is another factor for Alzheimer’s.
  • Vitamin B12: In addition to the research presented above, a small Finnish study published in the journal Neurology also found that people who consume foods rich in B12 may reduce their risk of Alzheimer’s in their later years. For each unit increase in the marker of vitamin B12, the risk of developing Alzheimer’s was reduced by two percent. Remember sublingual methylcobalamin may be your best bet here.
  • Eat a nutritious diet, rich in folate, such as the one described in my nutrition plan. Vegetables, without question, are your best form of folate, and we should all eat plenty of fresh raw veggies every day. Avoid supplements with folic acid, which is the inferior synthetic version of folate.
  • High-quality animal-based omega-3 fats, such as krill oil. (I recommend avoiding most fish because, although fish is naturally high in omega-3, most fish are now severely contaminated with mercury.) High intake of the omega-3 fats EPA and DHA help by preventing cell damage caused by Alzheimer’s disease, thereby slowing down its progression, and lowering your risk of developing the disorder.
  • Avoid and eliminate mercury from your body. Dental amalgam fillings, which are 50 percent mercury by weight, are one of the major sources of heavy metal toxicity. However you should be healthy prior to having them removed. Once you have adjusted to following the diet described in my optimized nutrition plan, you can follow the mercury detox protocol and then find a biological dentist to have your amalgams removed.
  • Avoid aluminum, such as antiperspirants, non-stick cookware, vaccine adjuvants, etc.
  • Exercise regularly. It’s been suggested that exercise can trigger a change in the way the amyloid precursor protein is metabolized, thus, slowing down the onset and progression of Alzheimer’s. Exercise also increases levels of the protein PGC-1alpha. Research has also shown that people with Alzheimer’s have less PGC-1alpha in their brains and cells that contain more of the protein produce less of the toxic amyloid protein associated with Alzheimer’s. I would strongly recommend reviewing the Peak Fitness Technique for my specific recommendations.
  • Avoid flu vaccinations as most contain both mercury and aluminum, well-known neurotoxic and immunotoxic agents.
  • Eat blueberries. Wild blueberries, which have high anthocyanin and antioxidant content, are known to guard against Alzheimer’s and other neurological diseases. Like any fruit though, avoid excesses here.
  • Challenge your mind daily. Mental stimulation, especially learning something new, such as learning to play an instrument or a new language, is associated with a decreased risk of Alzheimer’s. Researchers suspect that mental challenge helps to build up your brain, making it less susceptible to the lesions associated with Alzheimer’s disease.
  • Avoid anticholinergic and statin drugs. Drugs that block acetylcholine, a nervous system neurotransmitter, have been shown to increase your risk of dementia. These drugs include certain nighttime pain relievers, antihistamines, sleep aids, certain antidepressants, medications to control incontinence, and certain narcotic pain relievers. Statin drugs are particularly problematic because they suppress the synthesis of cholesterol, deplete your brain of coenzyme Q10 and neurotransmitter precursors, and prevent adequate delivery of essential fatty acids and fat-soluble antioxidants to your brain by inhibiting the production of the indispensable carrier biomolecule known as low-density lipoprotein.

Other Natural Treatments for Your Anti-Alzheimer’s Arsenal

Finally, there are a few other nutritional recommendations worth noting for their specific benefits in preventing and treating dementia. So, although your fundamental strategy for preventing dementia should involve a comprehensive lifestyle approach, you may want to consider adding a few of these natural dietary agents to your anti-Alzheimer’s arsenal. These four natural foods/supplements have good science behind them, in terms of preventing age-related cognitive changes:

  1. Coconut OilThe primary fuel your brain needs for energy is glucose. However, your brain is able to run on more than a single type of fuel, one being ketones (ketone bodies), or ketoacids. Ketones are what your body produces when it converts fat (as opposed to glucose) into energy.
    The medium-chain triglycerides (MCT) found in coconut oil are GREAT source of ketone bodies, because coconut oil is about 66 percent MCTs. In fact, ketones appear to be the preferred source of brain food in patients affected by diabetes or Alzheimer’s.
  2. Astaxanthin is a natural pigment with unique properties and many clinical benefits, including some of the most potent antioxidant activity currently known. As a fat-soluble nutrient, astaxanthin readily crosses your blood-brain barrier. One study found it may help prevent neurodegeneration associated with oxidative stress, as well as make a potent natural “brain food.” The molecules of astaxanthin neutralize free radicals and other oxidants without being destroyed or becoming pro-oxidants themselves in the process. It’s is a unique molecule whose shape allows it to precisely fit into a cell membrane and span its entire width. In this position, astaxanthin can intercept potentially damaging molecules before they can damage your cells. You can get some astaxanthin by taking krill oil, which is a fantastic omega-3 fat supplement. But you can boost your astaxanthin even MORE by adding a pure astaxanthin supplement to your nutritional regimen. For optimal absorption, make sure to take krill oil and/or astaxanthin with a fat-containing meal, since both are fat-soluble.
  3. Gingko bilobaMany scientific studies have found that Gingko biloba has positive effects for dementia. Gingko, which is derived from a tree native to Asia, has long been used medicinally in China and other countries. A 1997 study from JAMAshowed clear evidence that Gingko improves cognitive performance and social functioning for those suffering from dementia.
    Research since then has been equally promising. One study in 2006 found Gingko as effective as the dementia drug Aricept (donepezil) for treating mild to moderate Alzheimer’s type dementia. A 2010 meta-analysis found Gingko biloba to be effective for a variety of types of dementia.
  4. Alpha lipoic acid (ALA): ALA can stabilize cognitive functions among Alzheimer’s patients and may slow the progression of the disease.

Read the full article here: http://articles.mercola.com/sites/articles/archive/2013/06/13/alzheimers-dementia-treatment.aspx

For Men Only! Well not really.

L-arginine Benefits Amino Acid Powder for Men

Ready for weight loss click here….,

SmartGuy.com

Men are supposed to be among other things, physically strong. One of the most disturbing things that can accost any man, is the inability to function sexually. It is estimated that over 31 percent of men are affected by this condition. It is manifested through what is broadly known as erectile dysfunction or impotence. The good news is that you can take control of it and regain libido. Our bodies require amino acids in order to metabolize proteins. In total, you need twenty of them. Your body is only able to provide 10 out of the 20. This means that the balance must come from the food you eat.

L-arginine is one of those crucial amino acids whose lack can cause you to have impotence problems. L-arginine benefits not only men. Women too suffer from low libido. However, that is a subject for another day. Why is L-arginine so important to men? It is the originator of Nitric Oxide or NO. This element is important in the process of blood circulation. In the event of low circulation of blood, a man would not be able to have an erection. That is where problems in manhood stem from. L-arginine improves the flow of blood to the male sexual organ enabling it to attain the ideal size for sexual activity.

Other reported L-arginine benefits include increased sexual desire, endurance and satisfaction. If your body is found to be deficient of this important amino acid, you can supplement it. The supplement is found in powder form. There is scientific proof that supplements containing L-arginine have led to improved fertility especially in men with a low sperm count. In a certain test, one scientific journal reported that out of 29 men who were put on L-arginine for a period of 6 weeks, 9 of them had recorded substantial sexual improvement. When the trials started, the nine had low levels of nitric oxide. At the time of winding up the study, they had registered double the amount of NO (nitric oxide).

However, you should know that there are other factors that cause erectile dysfunction. These are diabetes and advancement of age. L-arginine benefits men whose impotence results from their bodies not secreting enough nitric oxide. This amino acid supplement will ensure that your body is able to produce sufficient nitric acid and make you feel like a man again. There are other benefits of this supplement. Of course we had to start with male performance as that is one of the marks of a true man. Other roles played by the powder supplement include improving your body’s immune system, regulating blood pressure, increasing your muscles as well as the speed at which your wounds heal.

But there is more. It is reported that as much as 80 Million Americans have cardiovascular disease. That is 1 out of 3 adults. In recent years, cardiovascular risk in women has been increasing and has killed more women than breast cancer. L-Arginine converts to Nitric Oxide in the body which may possibly help in the fight against heart disease and stroke and high blood plressure

Other benefits are as listed below:

  • Improves circulation of blood
  • Improves bone formation
  • Reduces body fat
  • Improves production of sperms
  • Reduces possibility of your blood clotting
  • Lowers your chances of getting a stroke
  • Can help you recover after a heart attack
  • Minimizes the risk of cancer by hindering the growth of tumors

If you are keen on increasing your sexual ability, perform satisfactorily and improve your health, this is an ideal supplement. It is safe and natural in comparison to Viagra. In terms of cost, L-arginine is relatively cheaper. You can find out more about the scientific tests by reading different scientific journals that have been published online. Above everything, you now have an opportunity of getting back to your youthful self. This is important towards the sustenance and enjoyment of relationships such as marriage where sexual activity plays a big role. Talk to your doctor about this. All supplements should be taken under the instructions provided.

Are you the Enterpreneur?


Creating Opportunity
by Jim Rohn

An enterprising person is one who comes across a pile of scrap metal and sees the making of a wonderful sculpture. An enterprising person is one who drives through an old decrepit part of town and sees a new housing development. An enterprising person is one who sees opportunity in all areas of life.

To be enterprising is to keep your eyes open and your mind active. It’s to be skilled enough, confident enough, creative enough and disciplined enough to seize opportunities that present themselves… regardless of the economy.

Click here for a jump start….,